The AIDS Foundation of South Africa (AFSA) was the first registered AIDS Non-Governmental Organisation in South Africa Focusing on Combination Prevention and Treatment, Child Protection and Wellbeing, Food Security and Income Generation, AFSA aims to deliver quality services to communities most in need. Policy and Practice through the promotion of equality, education and access to basic services is a cornerstone of these efforts. AFSA recognises that the HIV epidemic is rooted in social and relational phenomena conditioned by environmental, cultural, political and socio-economic drivers. Given the complex reality that HIV affects communities and subgroups differently, AFSA uses strategies that address the social and structural drivers of HIV/AIDS and integrates interventions into a broader sexual and reproductive health framework. AFSA focuses on geographies and populations with elevated risk, thereby effectively and efficiently maximizing prevention impact.