Pandha-25-P-0000_003354 Dna Aptamer-Based Therapeutic Development

  Address - Thailand

  Contact details - 565656565

  Tender notice no. - 76454545

  GT Ref Id - 105806740

  Document Type - Tender Notices

Description - Description: The objective of this contract is to conduct a two-year study on conjugated aptamers as antimicrobial agents to produce DNA aptamers conjugated with C1q- and Fc-domain proteins to create a biologic therapeutic with immunomodulatory antim icrobial activity against bacterial pathogens for wound infection. This shall include producing DNA aptamers that bind to the bacterial pathogen Pseudomonas aeruginosa; conjugating DNA aptamers to recombinant C1q protein and to recombinant IgG Fc domain protein to produce C1q- and Fc-conjugated DNA aptamers; validating that C1q- and Fc-conjugated DNA aptamers bind to Pseudomonas aeruginosa; and delivering C1q- and Fc-conjugated DNA aptamers to WR

Gt Ref Id - 105806740

Deadline - Apr 01, 2025